First, it is essential to eliminate all bacterial disease, if possible, before any form of reconstructive or implant therapy is performed. It is also advisable to closely follow the clinical treatment protocols of the implant manufacturers and to use only biocompatible materials. In the early days of dental implantology, the focus was predominantly on osseointegration, the bone healing mechanism, and the bone metabolism. In the 1980s and 1990s, at a time when the initial euphoria was beginning to dissipate and practitioners were increasingly confronted with long-term complications associated with implant restorations, the importance of the quantity, quality, and integrity of the soft tissue for the long-term success of implant treatments was already becoming apparent. A tight soft tissue seal against pathogenic bacteria is of great importance for maintaining long-term peri-implant health as well as overall health. Of course, there are differences not only in the myriad of implant systems available in terms of soft tissue response, but also in the various implant materials used today. For some years now, an interesting paradigm shift has been observed in science and newer materials, such as zirconia, are increasingly being investigated with regard to their soft tissue behavior. While more information and further scientific evidence is still needed, there are already promising findings on the highly beneficial soft tissue response to zirconia implants.